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pentobarbital decreases levels of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers raise rate of toremifene metabolism, reducing the continuous-condition focus in serum.pentobarbital will reduce the extent or impact of alosetron by influencing hepatic/intestinal enzyme CYP3A4 metabol